Don’t just buy Coq10 supplement off the shelf and consume it. You may be just throwing your hard earned money. Believe me when I say this. Primary Coenzyme Q10 (CoQ10) deficiency
is rare
.
If you are under 40 and an healthy individual, probability of having a coQ10 deficiency is low. CoQ10 deficiency  is characterized by exercise intolerance, recurrent myoglobinuria, developmental delay, ataxia, and seizures.

Minimum Blood work required for CoQ10 supplementation (Check with your physician)

If you are taking CoQ10 and blood thinners such as warfarin or aspirin, suggest you do two blood tests regularly. First one to determine if you have Coq10 Deficiency  and the second blood test called Prothrombin time (PT) that measures how long it takes blood to clot.  PT test results will ensure that your blood thinner (aspirin etc) dosage is effective and is NOT inhibited by COQ10 dosage

How to test for Coenzyme Q10 deficiency

Mitochondrial Profile Or CoQ10 Profile

Ask your physician to order a Mitochondrial profile blood test which help to determine CoQ10 level in your blood. . Mitochondrial profile blood test combines several tests, which together assess mitochondrial function and identify where the problem areas with energy production are. It is exceptionally useful for chronic fatigue sufferers as it gives clear indications for a treatment regime. Chronic fatigue syndrome is the symptom caused by mitochondrial failure. The job of mitochondria is to supply energy in the form of ATP (adenosine triphosphate). This is the universal currency of energy. It can be used for all sorts of biochemical jobs from muscle contraction to hormone production. When mitochondria fail, this results in poor supply of ATP, so cells go slow because they do not have the energy supply to function at a normal speed. This means that all bodily functions go slow.

The first part is called “ATP profiles” and has been developed by Dr John McLaren-Howard at Biolab in London. It measures the rate at which ATP is recycled in cells and because production of ATP is highly dependent on magnesium status so the first part of the test studies this aspect.

The second partof the test measures the efficiency with which ATP is made from ADP. If this is abnormal, then this could be as a result of magnesium deficiency, of low levels of Co-enzyme Q10, low levels of vitamin B3 (NAD) or of acetyl L-carnitine.

The third possibility is that the protein which transports ATP and ADP across mitochondrial membrane is impaired and this is also measured. To get the full picture of mitochondrial function the profile also measures levels of Co-enzyme Q10, SODase, NAD, L-carnitine and cell free DNA

Cost

The price of the  Mitochondrial Profile is estimated to be in the range of 250 to 400$. The price of the CoQ10 Blood test is estimated to be in the range of 100$

Prothrombin time (PT) Test

This test is essential to determine if your dosage of CoQ10 is inhibiting the effect of blood thinner medications such as warfarin or aspirin.

Prothrombin time (PT) is a blood test that measures how long it takes blood to clot. A prothrombin time test can be used to check for bleeding problems. PT is also used to check whether medicine to prevent blood clots is working.

A PT test may also be called an INR test. INR (international normalized ratio) stands for a way of standardizing the results of prothrombin time tests, no matter the testing method. So your doctor can understand results in the same way even when they come from different labs and different test methods. Using the INR system, treatment with blood-thinning medicine (anticoagulant therapy) will be the same. In some labs, only the INR is reported and the PT is not reported.

About 12 blood clotting factors are needed for blood to clot (coagulation). Prothrombin, or factor II, is one of the clotting factors made by the liver. Vitamin K is needed to make prothrombin and other clotting factors. Prothrombin time is an important test because it checks to see if five different blood clotting factors (factors I, II, V, VII, and X) are present. The prothrombin time is made longer by:

  • Blood-thinning medicine, such as heparin. Another test, the activated partial thromboplastin time (APTT) test, is a better test to find out if the right dose of heparin is being used.
  • Low levels of blood clotting factors.
  • A change in the activity of any of the clotting factors.
  • The absence of any of the clotting factors.
  • Other substances, called inhibitors, that affect the clotting factors.
  • An increase in the use of the clotting factors.

An abnormal prothrombin time is often caused by liver disease or injury or by treatment with blood thinners.

Another blood clotting test, called partial thromboplastin time (PTT), measures other clotting factors. Partial thromboplastin time and prothrombin time are often done at the same time to check for bleeding problems or the chance for too much bleeding in surgery.