Why this disclaimer on CoQ10 side effects is important

The U.S. Food and Drug Administration (FDA) do not regulate dietary supplements to the same standards to which they regulate prescription medicines. This means, different supplement manufacturers have different manufacturing standards. So if you buy two different brands of Coq10 of the same strength (let us say  CoQ10 100 mg), it is very likely the potency of the brands may vary significantly. Also the form of supplement you buy in health food stores or online may not be the same as the form used in research. So what does it tell?  Simply, there is no guarantee of strength, purity or safety of supplement grade CoQ10, and the side effects will vary between brands and the person who takes it

View this information with the disclaimer in mind.

Remember our body makes its own CoQ10 (unlike vitamins which needs to be taken as a food). So there are typically no side effects with taking CoQ10 as long as the dose is normal (below 200 mg at a time). Several studies have also confirmed this. People with Parkinson’s disease have been reported to be taking dosage as high as 2000 mg a day without adverse side effects. Does it mean that you will not have any side effects? No. Read the disclaimer above. Note following exceptions.

CoQ10 will inhibit Blood thinners

For patients who take blood thinners such as warfarin or aspirin, supplementing with CoQ10 can interfere with the medication rendering it ineffective. Coenzyme Q10 will react with warfarin. Similar to vitamin K, Coenzyme Q10 prevents warfarin from thinning blood. Make sure that you find your INR (international normalized ratio) and if it is within acceptable levels. Obviously you need to discus the CoQ10 side effects with your physician. The international normalized ratio (INR), prothrombin ratio (PR) and prothrombin time (PT) are measures of the extrinsic pathway of coagulation. They are used to determine the clotting tendency of blood. They are used in the measure of warfarin dosage, liver damage and vitamin K status. The reference range for prothrombin time is 7-10 seconds; the range for the INR is 0.8-1.2.

Do these blood tests on a regular basis (visit our blood test page for more information)

If you are taking CoQ10 and blood thinners such as warfarin or aspirin, suggest you do two blood tests regularly. First one to determine if you have Coq10 Deficiency  and the second blood test called Prothrombin time (PT) that measures how long it takes blood to clot.  PT test results will ensure that your blood thinner (aspirin etc) dosage is effective and is NOT inhibited by COQ10 dosage

CoQ10 Will complement ACE inhibitors

Also CoQ10 supplementation could lower blood pressure and this will complement to the effects of the medications Ramipril and Metoprolol. Ramipril is used alone or in combination with other medications to treat high blood pressure. It is also used to reduce the risk of heart attack and stroke in patients at risk for these problems and to improve survival in patients with heart failure after a heart attack. Ramipril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. Make sure that you discuss CoQ10 side effects with your doctor and monitor your blood pressure on regular basis. You don’t want your blood pressure to be too low.

CoQ10 with Red Yeast Rice Side effects

You would have seen many supplement manufacturers market Coq10 with Red yest rice (Chinese fermented rice). While this may be effective in lowering cholesterol level, patients with health conditions like liver disease or diabetes, should not take COQ10 with Red yeast rice without consulting their doctor. Red yeast rice can interact with blood thinners like warfarin, diabetes medicines, digoxin, and other blood pressure medications. Caution is advised before you start a COQ10 supplementation regime. Make sure to check with your physician so that health conditions and drug interactions can be monitored