Bio availability CoQ10

As a nutrient, CoQ10 is very difficult to be absorbed in the blood stream. Coenzyme Q10 (CoQ10) is highly hydrophobic (repelled by water) and insoluble in water due to its low polarity. This leads to low absorption, and bio-availability issues when we take it as supplements. Over 50% of an oral intake of CoQ10 is eliminated in the feces. CoQ10 is absorbed by the small intestine and transferred into the lymphatics, where it enters the blood stream. Absorption of CoQ10 is variable and depends in on food intake but also on the amount of lipids present in the food. If you take CoQ10 on on an empty stomach, absorption is much lower compared to when taken with food with high fat content. Also Ubiquinol form of CoQ10 ensures the most bio-availability than regular ubiquinone form. Read below the effectiveness of both forms in terms of bio-availability. As the CoQ10 absorption of is poor, consider buying a high quality Ubiquinol supplement with a good potency for maximum bio availability. Also currently there seems some trials to find if liquid form is better than capsules, but it is inconclusive as the jury is still out there.

Ubiquinol Vs Ubiquinone

Coenzyme Q10 exists in both ubiquinol and ubiquinone forms, and both are essential for cellular energy. Ubiquinone is the oxidized form of CoQ10 that has been taken as a supplement and studied for more than 40 years. In order to generate cellular energy, the body must convert ubiquinone into ubiquinol. The body is dependent on this conversion otherwise energy levels cannot be sustained, thus, both are critical to sustaining your body’s natural energy. The body’s ability to convert ubiquinone in to ubiquinol reduces as we age especially after 50 years of age. As a result, body doesn’t get the full effect of CoQ10. So traditional CoQ10 in ubiquinone form won’t help to stay young. Ubiquinol however is in reduced form allowing easier absorption within the body, providing a strong first-stage defense against cellular oxidative damage of the body’s cells, including proteins, lipids and DNA all of which need to be replenished to maintain optimum health. So if CoQ10 is taken in the form of ‘Ubiquinol’ it can absorbed much faster into the blood stream and better clinical improvements. ‘Ubiquinol’ has been researched and developed by Japanese scientists and several North American supplement manufacturers offer Ubiquinol CoQ10 in 100, 200, 300 mg strengths. Personally I take the 100mg capsules one a day with food. Several manufacturers sells CoQ10. Douglas Labs sells pharmaceutical grade CoQ10, but need to be prescribed by a doctor. You can also find numerous other brands like NOW, Life extension, nature made, Walgreen etc. Ubiquinol form of CoQ10 ensures the most bio-availability than regular form

Dosage and Administration

Supplemental coenzyme Q10 is available in capsule, tablet, softgel (gel cap), and chewable form. To improve its absorption, it can be taken with some type of oil (olive oil is recommended) or fat (peanut butter, for example). Most doctors recommend that CoQ10 be taken with meals to improve absorption. Patients with Congestive heart failure need to do a blood test. The test should indicate a CoQ10 reading of around 4 mcg/mL.  Those seeking for anti-aging effects  should take between 50 mg and 100 mg a day of ubiquinol in two divided doses to achieve a CoQ10 blood level of around 7 mcg/mL.  Dosage recommendations for people who take for Anti aging benefit range from 30 mg to 100mg a day. Higher daily doses are usually associated with a specific health condition and are often divided into 2 or 3 smaller doses (for example, one 50 mg soft gel taken 2 times a day instead of a single 100 milligram tablet taken once). If you are taking the enzyme for a heart condition, it may be 2 to 8 weeks before you notice any benefit, and you will need to continue taking the product to maintain any notable improvement.

Dosage Summary:

  1. Heart Patients —   Consult with your physician who will decide based on your current serumCoQ10 Levels
  2. Patents with Statin Drugs –  Same as above. Your serum Coq10 level will determine the dosage
  3. Patients with Parkinson disease –  Mixed review and results on treating the cause.  Check with your health care provider. Be skeptical about the results
  4. Below 40 years with no medical condition : There is no need for you take CoQ10; If you have extra cash to spend, donate it.
  5. Above 50 years with no medical condition: Try 50 to 100 mg with FOOD especially lipids (Olive oil); Remember higher dosage is not always better
  6. Anti aging Benefits: Start with 50mg twice a day and may increase up to 100 Mg. Monitor level with a physician on regular basis
  7. Never take on Empty Stomach. Consume it with food.
  8. Due to absorption issues, always take small doses multiple time instead of one single dose.
  9. Strictly buy  the Ubiquinol form preferably with Japanese ingredients. DO NOT buy if the bottle does not say ‘Ubiquinol’

Disclaimers: The above statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Please consult a Physician if you have medical needs